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KMID : 0357920110450010079
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Korean Journal of Pathology
2011 Volume.45 No. 1 p.79 ~ p.86
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Cytologic Features of Prostatic Adenocarcinoma in Urine: Comparison with Urothelial Carcinoma
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Kim Lucia
Song Joo-Young
Choi Suk-Jin
Park In-Suh
Han Jee-Young
Kim Joon-Mee
Chu Young-Chae
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Abstract
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Background : Prostate adenocarcinoma (PACa) cells are rarely identified in urine cytology specimens and might be easily overlooked or misdiagnosed as urothelial neoplasm when clinically unsuspected.
Methods : We reviewed 19 urine cytology specimens obtained from 13 patients with PACa and evaluated the characteristic features discriminating PACa from urothelial carcinoma (UCa). For comparison, 27 cases of high-grade UCa (HGUCa) and 10 cases of urothelial carcinoma in situ (UCis) were also evaluated.
Results : The urine cytologic evaluation of PACa revealed clustered cells forming 3-dimensional syncytial fragments with occasional microacinar grouping in a clean background. Most tumor cells were small and uniform with a high nuclear-to-cytoplasmic ratio and indistinct cell borders. The nuclei were round-to-oval and the cytoplasm was scanty and thin. One or more centrally-located prominent nucleoli were characteristically noted in one half of the cases. The nucleoli had a well-defined, large, round and eosinophilic appearance. In four high-grade cases, large tumor cells were encountered and had relatively monotonous cells with smooth-outlined cell clusters, well-defined and thin cytoplasm, and round nuclei with characteristic prominent nucleoli.
Conclusions : Combining the information of prostate cancer and the recognition of cytomorphologic features of PACa will help differentiate PACa from HGUCa and UCis.
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KEYWORD
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Prostatic neoplasms, Urine, Cytology, Carcinoma, transitional cell
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